تأثیر تمرین مقاومتی پیشرونده بر غلظت پلاسمایی آپلین پلاسما و مقاومت به انسولین در مردان میانسال مبتلا به دیابت نوع 2

Background: Apelin is a novel adipokine that is closely related with insulin resistance and&nbsp;type 2 diabetes. The purpose of the study was to determine the effects of progressive&nbsp;resistance training on plasma concentrations of plasma apelin and insulin resistance in&nbsp;middle-aged men with type 2 diabetes. Methods: twenty seven types 2 diabetic men selected as subjects and were randomly&nbsp;assigned into two exercise (n=15 aged 46.40 &plusmn; 3.02 yrs) and control (n=12 aged 45.06 &plusmn; 3.86&nbsp;yrs) groups. Resistance exercise training was done for 8 weeks (3 days/week, intensity: 30-&nbsp;70% 1RM) for experimental group. Before and after exercise plasma apelin level, insulin, glucose and insulin resistance (HOMA-IR) after a 12-h fasting was measured. Following the&nbsp;second blood sampling, data analysis was performed and p<0.05 was considered significant.&nbsp; Results: Finding showed that plasma apelin, insulin levels, HOMA-IR, fasting blood glucose&nbsp;(FBG) have significant changes in the exercise group compared to pre-exercise and control&nbsp;groups (p&le;0.05). Conclusion: It seems that low to moderate intensity resistance exercise training has&nbsp;significant effect on the amount of plasma apelin and insulin resistance in type 2 diabetic&nbsp;men. Apelin level may be effective to improve insulin resistance and glycemic control in type&nbsp;2 diabetic men.